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The Philadelphia 76ers are just 2.5-point underdogs against the Boston Celtics in the season opener for both teams at TD Garden on Wednesday, October 22, 2025. The game starts at 7:30 p.m. ET on NBCS-BOS and NBCS-PH.
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Celtics vs. 76ers Predictions for Wednesday
Our computer projections model for this game predicts a final tally of Celtics 122, 76ers 101.
- Moneyline Pick: Celtics (-136)
- Total Pick: Under 227.5 (computer predicts 223.4 points)
- Pick ATS: Celtics (-2.5)
Recent Celtics vs. 76ers Matchups
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| 3/6/2025 | Celtics | -14 | 217.5 | -962 | +627 | 123-105 BOS |
| 2/20/2025 | Celtics | -7 | 225.5 | -296 | +239 | 124-104 BOS |
| 2/2/2025 | Celtics | -12.5 | 224.5 | -680 | +490 | 118-110 BOS |
| 12/25/2024 | Celtics | -9.5 | 221 | -427 | +330 | 118-114 PHI |
Celtics 2024-25 Betting Trends
- Boston had 39 wins in 82 games against the spread last year.
- The Celtics' ATS record as 2.5-point favorites or more was 38-39 last season.
- There were 37 Boston games (out of 82) that hit the over last season.
- The Celtics went 60-18 in games they were favored on the moneyline last season (winning 76.9% of those games).
- Boston had a record of 60-17 in games it played as a moneyline favorite with odds of -136 or shorter last year (77.9%).
76ers 2024-25 Betting Trends
- Philadelphia won 29 games against the spread last year, while failing to cover 53 times.
- Against the spread, as underdogs of 2.5 points or greater, the 76ers went 21-27 last year.
- A total of 48 of Philadelphia's games last season hit the over.
- Last season, the 76ers won 10 out of the 53 games, or 18.9%, in which they were the underdog.
- Last season, Philadelphia won nine of its 48 games, or 18.8%, when it was the underdog by at least +115 on the moneyline.
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Celtics vs. 76ers Injury Report
Celtics
Celtics:
Jaylen Brown: Questionable (Hamstring),
Jayson Tatum: Out (Achilles)
76ers
76ers:
Jared McCain: Out (Thumb),
Paul George: Out (Knee),
Trendon Watford: Out (Hamstring)
Celtics vs. 76ers Game Time and TV Channel
- Game day: Wednesday, October 22, 2025
- Game time: 7:30 p.m. ET
- TV channel: NBCS-BOS and NBCS-PH
- Location: Boston, Massachusetts
- Arena: TD Garden
- Live stream: Watch this game on Fubo (Regional restrictions may apply)
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