The No. 3 Penn State Nittany Lions (3-0) meet a fellow Big Ten foe when they host the No. 6 Oregon Ducks (4-0) on Saturday, September 27, 2025 at West Shore Home Field at Beaver Stadium.
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Penn State vs. Oregon Matchup Info
- Game date: Saturday, September 27, 2025
- Game time: 7:30 p.m. ET
- Location: University Park, Pennsylvania
- Venue: West Shore Home Field at Beaver Stadium
- TV channel: NBC
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Penn State vs. Oregon Odds and Prediction
- Spread favorite: Nittany Lions (-3.5)
- Moneyline: Nittany Lions (-183), Ducks (+152)
- Total: 52.5 points
- Pick ATS: Oregon (+3.5)
- Pick OU: Under (52.5)
- Prediction: Oregon 32, Penn State 19
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Penn State vs. Oregon Betting Records and Insights
- Penn State is winless against the spread this season (0-3-0).
- Oregon has a record of 2-2-0 against the spread this year.
- The Nittany Lions have been favored by 3.5 points or more this season three times and failed to cover in all three.
- So far this season, two Penn State games have hit the over.
- This year, games featuring Oregon have gone over the point total twice.