Goedert was injured during the the Eagles' 32-21 loss on Monday Night Football and was expected to be placed on injured reserve, with the team monitoring his status before an official decision on Wednesday.
Commanders linebacker Jamin Davis appeared to grab Goedert's face mask during an attempted tackle as the tight end was hit by defensive tackle John Ridgeway, who knocked the ball loose for a crucial fumble.
Ridgeway's weight was on top of Goedert as he was brought down to the ground and it appeared that his left shoulder took much of the impact during the tackle, which led to Goedert being taken to the sideline before re-entering the game.
The Commanders took possession and later connected on a 55-yard field goal to extend their lead to six points.
All NFL players are effectively ruled out for at least four games after being placed on injured reserve.
Goedert currently ranks second among all Eagles players with 544 receiving yards and three receiving touchdowns.
Rookie Grant Calcaterra and second-year player Jack Stoll is expected to have extended roles at the tight end position in Goedert's reported absence.
Additionally, Tyree Jackson, who is recovering from a torn ACL, could also return to the Eagles' lineup soon, according to ESPN.