The UEFA Champions League drama heats up right away on Wednesday.
Groups E and F carry the most potential in terms of drama and Group F will be in the spotlight by its own in the early window.
Real Madrid appear to be safe in its quest to win the group, but it needs to confirm that spot with a win over Celtic, while RB Leipzig needs a result against Shakhtar Donetsk to advance to the knockout round.
Group E features a head-to-head showdown between AC Milan and RB Salzburg for the second advancement spot alongside Chelsea.
The other two groups in action on Wednesday have little to play for, but there is still one edge to be found among those four contests.
Wednesday UCL Picks
Overall Record: 41-40 (16-12 UCL)
Real Madrid (-1.5; -145) vs. Celtic (1:45 p.m. ET)
Real Madrid needs a win over Celtic at the Bernabeu to confirm first place in Group F.
That should be an easy task for Los Blancos against a side that struggled to find its footing in the group stage.
Celtic comes into Matchday 6 with 10 goals conceded in the group. The Scottish side lost by three goals to Real Madrid on Matchday 1.
Celtic has not been impressive at any point of the group stage and this should be a game in which Real Madrid control from the start.
Real Madrid owns a 4-1 advantage at home in Group F and it could use a strong performance after a letdown against Leipzig on Matchday 5.
Shakhtar Donetsk vs. RB Leipzig (-130) (1:45 p.m. ET)
RB Leipzig needs to avoid a defeat against Shakhtar to confirm its spot in the round of 16.
The German side still has an outside chance of winning the group if Real Madrid slips up, so it should not just be playing for a draw.
First place in the group comes with a potentially easier round-of-16 matchup against a second-place team and that is what Leipzig should be chasing on Wednesday.
The Timo Werner-Christopher Nkunku duo has paid dividends for Leipzig already and the attack of the German side could be too much for Shakhtar to handle.
AC Milan vs. RB Salzburg (Over 2.5 Goals; -135) (4 p.m. ET)
The AC Milan-RB Salzburg clash is the most important one of the six-game late slate.
The two sides are directly playing for second place in Group E behind Chelsea.
I expect a wide open game between the Italian and Austrian sides with so much on the line from the start. Salzburg scored in every UCL group stage game this season and Milan produced multiple goals in four of its last six matches across all competitions.
Milan should go through with a win or draw at home, but it will be tough to earn against a Salzburg side with nothing to lose on the road.
FC Copenhagen vs. Borussia Dortmund (-140) (4 p.m. ET)
Borussia Dortmund and FC Copenhagen have nothing to play for on Wednesday.
Dortmund is already through as the second-place side in Group G, but it should throw out a competitive lineup since it plays Bochum on the weekend in the Bundesliga.
Copenhagen has not scored in five group games and it conceded on 11 occasions against Dortmund, Manchester City and Sevilla.
Copenhagen produced better performances in the second half of the group stage, but Dortmund should have too much quality for the Danish side to earn a result.