The New York Mets are 4-1 against the Washington Nationals this season.
The Mets opened their second series of the season against their National League East rival with a 4-2 victory on Tuesday.
New York is poised to put another number in the win column behind Tylor Megill on Wednesday.
The Mets have been fantastic against the run line in Megill's starts and in victories over the Nationals.
Sandy Alcantara and the Miami Marlins are one of four teams looking up at the Mets in the NL East standings.
Alcantara toes the rubber on Wednesday afternoon in what could be a low-scoring affair with the Arizona Diamondbacks.
Alcantara has been consistent in the strikeout department and he could produce his highest total of the young season against one of the worst lineups against right-handed pitchers.
Wednesday MLB Picks
Sandy Alcantara (MIA) Over 5.5 Strikeouts (+105)
Sandy Alcantara hurled either five or six strikeouts in each of his last five starts.
Alcantara faces an Arizona offense that strikes out the most against right-handed pitching.
The Diamondbacks fanned 219 times in 739 at-bats over 31 games versus right-handed hurlers.
Additionally, Arizona has the fourth-most strikeouts in day games behind Minnesota, Oakland and Boston.
Alcantara's 16 walks are a concern, but if he limits those, he could go deep into the game. He threw six or more innings in three of his four starts with three walks or fewer.
New York Mets (-1.5; -110) at Washington Nationals
The New York Mets have a significant edge in the pitching matchup on Wednesday.
Tylor Megill has been fantastic at the top of the Mets' rotation alongside Max Scherzer.
Aaron Sanchez conceded 13 earned runs in 13.2 innings of work. He allowed six hits in each of his three appearances.
The Mets are 5-1 when Megill starts and they covered the run line in four of those five victories.
Megill was superb in his season-opening start against the Nationals on April 7. He struck out six batters and conceded three hits over five frames.
The Mets should not have to score a ton of runs to support Megill, but they may end up with a large total anyway given how poor Sanchez has pitched.